OPTOGENETIC MODULATION OF GUANINE NUCLEOTIDE EXCHANGE FACTORS OF RAS SUPERFAMILY PROTEINS DIRECTLY CONTROLS CELL SHAPE AND MOVEMENT

Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement

In this article, we provide detailed protocols on using optogenetic dimerizers to acutely perturb activities of guanine nucleotide exchange factors (GEFs) specific to Ras, Rac or Rho small GTPases of the migratory networks in various mammalian and amoeba cell lines.These GEFs are crucial components of signal transduction networks which link upstrea

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Social Media Listening to Understand the Lived Experience of Individuals in Europe With Metastatic Breast Cancer: A Systematic Search and Content Analysis Study

BackgroundDespite a wealth of real-world data on metastatic breast cancer weekend friend juneshine (mBC), insights into the lived experience are lacking.This study aimed to explore how the lived experience of mBC is described on social media.MethodsA predefined search string identified posts relevant to the lived experience of mBC from Twitter, pat

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Diagnostic Performance of Xpert MTB/RIF Ultra Compared with Predecessor Test, Xpert MTB/RIF, in a Low TB Incidence Setting: a Retrospective Service Evaluation

ABSTRACT The aim of this study was to evaluate the performance of Xpert MTB/RIF Ultra (Ultra) compared with its predecessor, Xpert MTB/RIF (Xpert), in the diagnosis of tuberculosis (TB) in a low TB incidence country.Retrospective analysis was billionaire boys club discount code 2023 performed on 689 clinical samples received between 2015 and 2018,

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